Bio-Regenerative Skin Booster
Plump, Calm, Repair - From the Inside Out. A next-generation bio-stimulatory injectable that signals your skin to heal, hydrate, and strengthen for a smoother, healthier, more resilient complexion.
Welcome to Amer Clinic, London, the private Kensington aesthetic clinic led by Dr. Priyanka Chadha, a globally recognised Consultant Plastic Surgeon. Polynucleotides are the next evolution in skin health, stimulating your skin to hydrate, heal and regenerate naturally for a visibly smoother, stronger, and more radiant complexion.
Polynucleotides London | Bio-Regenerative Skin Booster | Amer Clinic
How Polynucleotides Work
Polynucleotides are purified chains of nucleotides that act as powerful bio-signalers. Once injected in micro-deposits, they attract water to deeply hydrate the skin, modulate inflammation to calm sensitivity, and stimulate fibroblasts to produce new Type I & III collagen and elastin. Over the following weeks, the dermis becomes denser, smoother, and more elastic with a healthier glow, all without adding artificial volume.
Once injected, polynucleotides act as intelligent messengers within the skin. They bind water molecules for deep, sustained hydration while supporting tissue repair at a cellular level. By activating fibroblasts, they encourage the production of collagen and elastin, improving skin density and elasticity over time. Their anti-inflammatory properties also help calm sensitivity and redness, making them suitable for compromised or reactive skin. Rather than adding volume, polynucleotides improve skin quality from within, resulting in smoother texture, increased resilience, and a naturally healthy glow that develops progressively.
Book a Consultation
Your Guide to a PN Session
An initial improvement in hydration and glow can appear within 1-2 weeks. The full benefits of increased firmness and elasticity build over 4-8 weeks and continue to improve after the course is complete. Hydration and skin comfort often improve within the first one to two weeks following treatment. As collagen and elastin production increases, skin firmness and texture continue to improve over the next four to eight weeks. Results develop gradually, creating a natural-looking enhancement rather than an instant change. With a full course of treatments, skin quality continues to strengthen, delivering longer-lasting improvements in tone, resilience, and overall appearance.
Discomfort is minimal. A topical anaesthetic can be used, and the small "bee-sting" bumps from the micro-deposits typically flatten within a few hours. Most patients find the treatment very manageable. A topical anaesthetic is applied beforehand to reduce sensitivity, and the injections are delivered in small, controlled micro-deposits. You may feel brief pinching sensations, but discomfort is minimal and short lived. Any small raised areas typically settle within a few hours, allowing you to return to daily activities quickly and comfortably.
No. Polynucleotides are not volumising fillers. They work at a cellular level to condition and regenerate your skin without changing your natural facial shape. Polynucleotides do not behave like dermal fillers and do not create volume. Instead, they improve skin quality by supporting hydration and cellular repair. Your facial structure and expressions remain unchanged, making this treatment ideal for patients seeking subtle rejuvenation. The results are gradual and natural, enhancing skin texture and strength without puffiness or an over-treated appearance.
The active ingredient is high-purity, salmon-derived DNA (PN/PDRN), which is where the nickname comes from. The final medical product is stringently purified and protein-free, making it suitable for most patients. We will review your medical history and any sensitivities during your consultation. Polynucleotides are derived from highly purified salmon DNA, which is why the nickname exists. The final medical-grade product contains no proteins and undergoes rigorous purification to ensure safety and compatibility. This biocompatible structure closely matches human DNA, allowing it to work effectively within the skin. Suitability is always assessed during consultation, including any allergies or sensitivities, to ensure treatment is appropriate for you.
The Amer Clinic Experience
Frequently Asked Questions
Polynucleotides are purified DNA molecules that stimulate collagen, calm inflammation, and hydrate deeply rebuilding skin structure naturally from within.
They don’t add volume. Instead, Polynucleotides trigger your body’s repair mechanisms to improve skin quality, elasticity, and hydration at a cellular level.
Popular areas include under-eyes, face, neck, and hands. They're also ideal for sensitive skin or as part of post-procedure recovery protocols.
A course of 3-4 sessions spaced 2-4 weeks apart is typical, with maintenance treatments every 6-12 months depending on your skin’s needs.
Yes. They pair well with lasers, microneedling, peels, or injectables and help reduce downtime while boosting overall results and skin recovery.
Invest in Skin that Repairs, Restores, and Glows
Schedule your private consultation to discover the bio-regenerative power of Polynucleotides at Amer Clinic, Kensington.
Book a Consultation